Introducing the BiOptix 404pi

BiOptix offers an affordable and powerful solution for drug discovery scientists that require label-free, real-time detection of biomolecular interactions. The unique SPR-enhanced instrumentation offers precise measurement of kinetics, affinity constants, concentration analysis and modern, easy-to-use analytical software.


Features of the BiOptix 404pi include:

  • Phase-based SPR for high sensitivity
  • 4 injector / 4 flow cell design for increased throughput, allowing for multiplexed kinetic measurements
  • Increased uptime – unique fluidic system – no annual replacement required
  • Standard & custom surface chemistries
  • In-line degassing
  • Supplied with industry standard Scrubber 2 software
  • Cost effective and simple to operate

Biological Applications

  • Protein-small molecule interactions
  • Protein-protein interactions
  • Antibody-antigen interactions
  • Kinetics & affinities
  • Affinity maturation
  • Epitope binning
  • Nucleic acid-protein interactions
  • Biomolecule concentration measurements
  • Immunogenicity screening

Four Injector Design

A unique feature of the BiOptix 404pi is the use of a four needle autosampler and four parallel flow cells. This allows operation in a mode that provides four times the throughput of an ordinary SPR instrument, while maintaining the sensitivity that users demand. The 404pi can also be operated in a traditional mode for more detailed analysis of molecular interactions. The 404pi is capable of using 96 well plates.

For additional information or to request a product demonstration, please contact a BiOptix product specialist at: 303-545-5550.